Green tea and red wine may seem like simple dietary choices—but beneath the surface, they harbor compounds with remarkable ...

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32951-4 ...

EGCG has been studied extensively but has never worked as a drug for Alzheimer's because it's ability to dismantle tau fibers works best in water, and it doesn't enter cells or the brain easily.

(a) Structure of epigallocatechin gallate (EGCG). (b-d) Pre-treatment of authentic HCoV-229E, HCoV-OC43 or murine coronavirus MHV-A59 virions with EGCG for 10 min at 37°C inhibits infection of ...

The current study extracted tau protein aggregates from brain tissue with Alzheimer’s disease and incubated them with EGCG for varying amounts of time. Within 24 hours, all tau protein aggregates had ...

Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids. Scientific Reports, 2023; 13 (1) DOI: 10.1038/s41598-023-35212-6 ...