Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride. Distinguishing these ...

Mutations, drugs drive cancer by blurring growth signals. ScienceDaily . Retrieved May 22, 2025 from www.sciencedaily.com / releases / 2018 / 08 / 180831175032.htm ...

Dr. Rubin, Blattner and team have identified the molecular mechanisms by which SPOP gene mutations, which define one of the most frequently occurring prostate cancer subtypes, drive prostate cancer.

But a study of the eyelids of four people who don’t have cancer reveals that such mutations “are staggeringly common in normal skin,” says Philip Jones, a clinical scientist at the ...

For the first time, research has provided an unbiased estimate of the how many mutations are needed for a cancer to develop. A research team from the Wellcome Trust Sanger Institute and their ...

Other common mutations include changes to the epidermal growth factor receptor (eGFR) and BRAF. Many of these genes have drugs now that can target them and prevent them from causing cancer progression ...

The number of mutated genes that drive the development of cancer is greater than had been thought, research shows. However, as well as these "driver" mutations, each type of cancer cell carries many ...

Cancer is typically ... response," says Dr. Demichelis. The researchers also report that future targeted cancer therapy may depend on identifying complex sets of genetic mutations and ...

In the study, the team developed an approach to discovering which genes are implicated in cancer evolution and how many mutations in those genes drive cancer. In the future, such approaches could ...

Lung cancer is by far the leading cause of cancer death worldwide. Efforts to identify the genetic mutations that drive the disease have led to targeted treatments that improve life expectancy for ...

The findings suggest that mutations in regulatory parts of the genome, in addition to those in protein-coding sequences, may be a key mechanism causing the growth of certain types of cancer. “I am ...

Photo by Wendell Lim Laboratory Genetic mutations in a form of non–small cell lung cancer (NSCLC) may drive tumor formation by blurring cells’ perception of key growth signals, according to a new ...