“Our discovery of a dopamine-based arousal rhythm generator provides a novel and distinct target for treatment, which should aim at correcting or silencing this clock to reduce the frequency and ...

Université de Genève. "The dopamine clock: How your brain predicts when you'll feel good." ScienceDaily. ScienceDaily, 9 June 2025. <www.sciencedaily.com / releases / 2025 / 06 / 250609054401.htm>.

When dopamine-producing neurons in the brain's reward center were disrupted, the behavioral rhythms stopped, indicating that these dopamine neurons are a key factor in bipolar mood swings.

A manic or depressed state may arise depending on how these two clocks, which run at different speeds, align at a given time. Notably, the authors say this second dopamine-based clock probably ...

When they disrupted dopamine-producing neurons in the brain's reward centre, these rhythms ceased, highlighting dopamine as a key factor in the mood swings of bipolar disorder.