Sulfa drugs are widely used in the treatment and prophylaxis of Pneumocystis carinii pneumonia. The nucleotide sequences of the sulfa target enzyme, dihydropteroate synthase (DHPS), differed ...

Dihydropteroate synthase (DHPS) is a crucial enzyme in the folate biosynthetic pathway, catalysing the formation of essential folate cofactors that underpin DNA synthesis and cellular functioning.

Edmund M. Wise, Martha M. Abou-Donia, Sulfonamide Resistance Mechanism in Escherichia coli: R Plasmids Can Determine Sulfonamide-Resistant Dihydropteroate Synthases, Proceedings of the National ...