In 2017, Jesse Boehm, a genomics scientist at the Broad Institute of MIT and Harvard, and his team had used multiple guide RNAs to perform a genome-wide screen in cancer cells lines from 1,000s of ...

Introduction: Why CRISPR Screening Still Feels Slow CRISPR-Cas9 technology has revolutionized gene editing, but biotech teams frequently find themselves bogged down by unexpectedly lengthy CRISPR ...

Using CRISPR-Cas13 to edit RNA and avoid off-target activity, the researchers systematically profiled nearly 6,200 gene pairs of long noncoding RNAs (lncRNAs) and nearby protein-coding genes ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That''s where Perturb-Seq comes in-a method ...