Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Autophagosomes take up damaged molecules or organelles and carry this cargo to the lysosomes. When de Duve observed autophagosomes, he realized that cells could degrade their own components and ...

More importantly, they found that this spreading can be prevented by the removal of damaged lysosomes from cells via a process known as lysophagy. Alpha-synuclein was first linked to Parkinson's ...

Cells have various quality control mechanisms to detect and repair dysfunctional mitochondria, but when the organelles are too damaged, the cell degrades them using lysosomes. We wanted to determine ...

Here the authors show that lysosomes and lysosomal acid lipase play a critical role in adipocyte lipolysis with fasting in mice. Damaged lysosomes are eliminated by lysophagy, yet the regulatory ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for breaking down larger molecules such as proteins, fats and carbs. Lysosomal exocytosis occurs when the ...

This process, known as autophagy, is like a self-cleaning mechanism for cells, helping the cells stay healthy by getting rid of damaged parts ... type of vesicle called lysosome.