This study reveals that RNA polymerase I uses a unique stalling mechanism at abasic DNA sites, distinct from RNA polymerase II. Pol I’s tendency to stall prevents the production of defective ...

Greedy accumulation-directed evolution generated multi-site combinatorial mutants of T7 RNA polymerase (T7 RNAP), breaking ...

The team tested the Pol 1 inhibitor BOB-42 in animal models, including patient-derived tumors containing the same key genetic markers. The drug reduced tumor growth by up to 77% in melanoma and ...

Boston startup Ascidian Therapeutics charts vision for therapies that ‘rewrite RNA’ The new biotech company raised $50 million for its unique take on RNA editing therapies.

This allows them to be inserted into the nascent RNA. Remdesivir (RDV) was developed to fight the Ebola virus back in 2014 but was repurposed against the current coronavirus disease 2019 (COVID-19).

Scientists provide fresh insights on the origins of life, presenting compelling evidence supporting the 'RNA World' hypothesis. The study unveils an RNA enzyme that can make accurate ...

PCR, or Polymerase Chain Reaction, is a revolutionary molecular biology technique that allows for the rapid amplification of specific DNA sequences. It is an essential tool in various fields, ...

What’s driving the RNA age is this molecule’s dazzling versatility. Yes, RNA can store genetic information, just like DNA. As a case in point, many of the viruses (from influenza to Ebola to ...