In spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin ...

Similarly when transcription factor unbinds, the DNA supercoils that were constrained between the transcription factor and the closest RNAP to the promoter diffuse, and the DNA segment returns to ...

The binding of proteins to DNA is crucial for producing other proteins, ensuring that all the necessary processes in cells ...

A research team at the University of Cologne has developed a method called DynaTag, which can detect the binding of proteins ...

September 23, 2021 Transcription factors bound to DNA. Molecular model of the Oct4 (pink) and Sox2 (green) transcription factors bound to a molecule of DNA (red and blue).

Transcription repression near the promoter region. Molecules can interfere with RNA polymerase binding. An inactive repressor protein (blue) can become activated by another molecule (red circle).

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

DNA has to be carefully organized and packaged so it will fit into the nucleus of cells; compacted DNA that's been organized with other proteins is known as chromatin. The structure of the genome can ...

Transcription of a gene begins when RNAP binds to a 'promoter' DNA sequence and ends at a 'terminator' sequence where the mRNA copy is released.

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...

Each of the subunits and DNA chains is colored differently. (B) The comparison of SigI and a canonical σ 70 factor in -35 and -10 promoter recognition. view more Credit: LI Jie and FENG Yingang ...