DNA gyrase, a bacterial type II topoisomerase, is instrumental in maintaining DNA supercoiling during replication and transcription. Owing to its absence in higher eukaryotes, it represents an ...

Some DNA supercoiling is essential to make DNA accessible to allow the cell to read and make copies of the genetic information, but either too little or too much supercoiling is detrimental. For ...

DNA gyrase operates like a tiny molecular machine, carefully twisting and stabilising bacterial DNA. This twisting, known as supercoiling, is similar to winding an elastic band: as it twists, it ...

The enzyme wraps DNA in a “figure-of-eight” loop, then precisely breaks and passes strands through each other, resealing them afterward. This is a delicate process—if the DNA remained broken ...

It showed that albicidin forms an L-shape, enabling it to interact with both the gyrase and the DNA in a unique way. In this state gyrase can no longer move to bring the DNA ends together. The effect ...