Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation.

such as replication and transcription, and the plausible roles of different subfamilies of DNA topoisomerases in each of these processes. The presence of at least one IA enzyme in all known living ...

DNA topoisomerase 1 is an enzyme present in ... thus relaxing the topological stress generated during replication and transcription; secondly, the inhibitors prevent the cuts in the DNA from ...

Anti-cancer drugs like topoisomerase I (TOP1) inhibitors work by disrupting DNA replication in cancer cells. As a cell's double helix-shaped DNA strands split apart and begin to copy themselves ...

They can change the geometry and topology of DNA, thus maintaining a stable genome. In E. coli, topoisomerases work tirelessly during and after replication to maintain healthy levels of ...

Cells have to carry around a massive amount of genetic material, and usually, that DNA is about 1,000 times longer than the cell where it lives. It can’t just be jammed in there though; it has to be ...

The paper, "Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity," published Oct. 17 in Cell. During DNA replication -- as a replisome splits two DNA strands and ...

These topoisomerases are the main research ... transcription is suggested to collide with the duplication of DNA, i.e., replication, which is needed for eventual cell division.

DNA topoisomerase 1 is an enzyme present in ... thus relaxing the topological stress generated during replication and transcription; secondly, the inhibitors prevent the cuts in the DNA from ...

This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to DNA strand breaks, preventing the replication of diseased cells.

there was an increase in both replication and transcription activity, significantly raising the likelihood of encounters between replisomes or transcription complexes and topoisomerase-DNA ...