The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a ...

Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading ...

To get there, many other steps of DNA replication still need to be understood, such as how the melted DNA origin is opened up even more fully to produce the Y-shaped DNA replication fork. “The DNA ...

Dr. Tsubouchi concludes, "We propose that slow replication forks are not the manifestation of replication impediments but rather an integral feature of DNA replication in ES cells.

Grant D. Schauer, Michael E. O’Donnell, Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork, Proceedings of the National Academy of Sciences of the United ...