The DNA polymerase delta enzyme selects the right bases, and proofreads the sequences formed, as well as helping to repair the rare errors. The enzyme is composed of a core made up of p125 and P50 ...

MichaelTaylor3d Functions of DNA polymerase enzymes Since Arthur Kornberg was awarded the Nobel Prize in 1959 for determining the roles of DNA polymerases during DNA replication, it has been ...

They determined the holoenzyme structure in complex with DNA using cryo-electron microscopy at the global resolution of ~2.8 Å. According to the findings, the holoenzyme possesses an architecture ...

The Polymerase Chain Reaction (PCR) is a technique for the amplification of DNA in vitro (this describes experiments with cells outside their normal environment). PCR amplifies DNA using ...

High-resolution crystal structure reveals a new pathway for RNA during a nontraditional form of transcription -- the process by which RNA is produced from a DNA template. Caught during the act of ...

The researchers observed that, on average, a single DNA polymerase molecule remained bound to the nucleic acid at the junction for slightly more than one second—far from the continuous binding that ...

Letter Published: January 2001 Crystal structure of a DNA-dependent RNA polymerase (DNA primase) Martin A. Augustin, Robert Huber & Jens T. Kaiser Nature Structural Biology 8, 57–61 (2001) Cite ...

A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-43735-9 ...

The helicase unzips the double-stranded DNA for replication, making a forked structure. The primase generates short strands of RNA that bind to the single-stranded DNA to initiate DNA synthesis by ...