Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled ...

revealing how it wraps DNA through outstretched protein arms to form the figure-of-eight shape. This finding updates the conventional view of gyrase’s mechanism, which has been studied for decades.

Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications.

revealing how it wraps DNA through outstretched protein arms to form the figure-of-eight shape. This finding updates the conventional view of gyrase’s mechanism, which has been studied for decades.

Previous studies had identified one resistance mechanism caused by the production of pentapeptide repeat proteins (PRPs), a family of molecules that also act as DNA gyrase inhibitors. One of these ...

“This is the first step of the mechanism that prompts the enzyme for resolving DNA entanglements,” Lamour said. “DNA gyrase, now surrounded by a tightly supercoiled loop, will cut one DNA helix in the ...

"Human cells have similar mechanisms to resolve DNA twists but using different molecular machines, and our work on DNA gyrase in bacteria gives us valuable insights into the generalised mechanisms ...