More information: James Wordsworth et al, A novel theory of ageing independent of damage accumulation, Aging (2023). DOI: 10.18632/aging.204956 ...

In a theory that challenges what we know about aging,João Pedro de Magalhães, a molecular biogerontologist at the University ...

Scientists have developed a chemical method to reverse aging in human cells without the need for genetic modification.

Premature aging disorders, such as Cockayne syndrome, are also characterized by DNA damage; the usual DNA repair mechanisms malfunction, leading to stalled RNA polymerases at sites of damage ...

In their pursuit to discover the mechanism behind how RVCL does its damage, researchers found some clues to the DNA damage theory of aging. "It seems that accelerated DNA damage in RVCL causes the ...

“DNA damage,” the authors wrote, “functionally underlies major aspects of normal aging.” Understanding just how the aging symptoms occur requires looking at each step in the process.

Science Mutant mice support aging theory CBC News · Posted: May 26, 2004 3:37 PM PDT | Last Updated: May 26, 2004 ...

New research uncovering the DNA-damaging mechanism by which a mutated gene causes a rare, fatal disease may have repercussions for the treatment of many other diseases linked to aging, including ...

Regular aerobic exercise later in life prevents genomic instability characterized by DNA damage and telomere dysfunction, according to a study from the Department of Internal Medicine at the ...

Chauvin, S. D., et al. (2024). Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.