More information: Katelyn Burleigh et al. Human DNA-PK activates a STING-independent DNA sensing pathway, Science Immunology (2020). DOI: 10.1126/sciimmunol.aba4219 ...

A protein called STING, previously shown to control a pathway that contributes to antiviral ... In healthy human cells, DNA is packaged up inside the nucleus and mitochondria.

The cGAS–STING pathway is part of the innate immune system and is involved in the detection of cytosolic deoxyribonucleic acid (DNA). Post-detection, this pathway triggers the defense mechanisms ...

Nevertheless, they suggested, “The discovery of T EM cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-kB pathway presents this pathway as a potential target to ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...

DNA can break in response to natural and environmental factors. Thankfully, our bodies have dedicated enzymes and pathways which can glue our broken DNA back together through several different ...

STING (stimulator of interferon ... the presence of double-stranded DNA in the cytoplasm (a sign of infection or damage). Aduro has established pioneering expertise in studying proteins that make up ...

In particular, we have identified base-specific recognition of the PAM sequence and the positioning of target and non-target DNA strands in the ... to bind the signaling protein STING with subsequent ...

A protein called STING, previously shown to control a pathway that contributes to antiviral ... In healthy human cells, DNA is packaged up inside the nucleus and mitochondria.