Introduction Cytotoxic T lymphocytes (CTL) are the arm of the adaptive immune system specialised in killing virally infected or malignant cells. They are classically derived from CD8 + naive T cells ...

CD8+ cytotoxic T lymphocytes can kill host cells infected with various microorganisms and single individual cancer cells through direct cell-to-cell contact, but their ability to destroy a target ...

Cytotoxic lymphocytes are crucial to our immune system, primarily eliminating virus-infected or cancerous cells via perforin/granzyme killing. Perforin forms transmembrane pores in the plasma membrane ...

Initial reports of CD4 T cells with cytotoxic characteristics from cultured CD4 T cell lines and clones (1 – 5) were met with doubt as to whether these CD4 T cells were in fact true cytotoxic T ...

Results: DR treated mice exhibited cardiac CD8 + T-cell infiltration alongside hallmarks of DR cardiomyopathy, including declined ejection fraction (EF) measured by echocardiography, cardiac cell ...

Generation of broad cytotoxic T-lymphocyte responses against multiple epitopes and tumor-associated antigens (TAAs) may provide effective immunotherapy in patients with cancer. We evaluated a ...