CRISPRi allows biologists to turn down the activity of specific genes in a cell. CREME lets scientists make similar changes in the virtual genome and predicts their effects on gene activity.

Automated machine learning and data fusion predicts depletion in CRISPRi essentiality screens. Credit: Genome Biology (2024). DOI: 10.1186/s13059-023-03153-y ...

Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration. Genome Biology, 2024; 25 (1) DOI: 10.1186/s13059-023 ...