Project description The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the committed step in the biosynthesis of prostaglandins. COX-1 and COX-2 are the pharmacological targets of nonsteroidal anti ...

TPST-1495 is designed to be an oral, highly specific, antagonist of the EP2 and EP4 receptors, sparing the EP1 and EP3 receptors and the COX enzymes. Preclinical studies suggest that blocking EP2 and ...