Now preorganization of a DNA–ligand complex to a metal-binding site enables site-selective conjugation of a DNA strand to lysine residues of wild-type proteins and antibodies.

To obtain the covalent complex, mutant protein was incubated with a synthetic oligonucleotide (supplied by Sigma-Aldrich) of sequence 5 ′ AATGCGCT↓TTGGG3 ′ (topoisomerase I preferred cleavage site ...

A Protein Complex That Untangles DNA. ScienceDaily. Retrieved June 4, 2025 from www.sciencedaily.com / releases / 2006 / 07 / 060716090339.htm. Karolinska Institutet.

Characterising Protein - DNA Complexes Summary. Proteins and nucleic acids often bind in stoichiometric ratios above 1:1, resulting in phenomena such as cooperativity or allosteric hindrance.

We took inspiration from a sequence-specific, covalent protein–DNA conjugation method based on the Rep nickase of a porcine circovirus called “HUH tag”. Though wild-type HUH protein has no detectable ...

A recent article in Small describes a modular platform for assembling protein-DNA composites using covalent, site-specific conjugation. This method enables the formation of stable structures with ...

The MEILB2 protein sandwich carries the BRCA2 protein precisely to the DNA break points. To determine the structure of this BRCA2 complex, the researchers used X-ray crystallography.

I read the input doc and it says Defining covalent bonds between or within polymer entities is not currently supported. I'm not sure what polymer exactly means in the context.So I use 1K4T, a ...

The COVID-19 pandemic, exacerbated by persistent viral mutations, underscored the urgent need for diverse inhibitors targeting multiple viral proteins. In this study, we utilized covalent DNA-encoded ...

Protein complex discovered to control DNA repair. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 01 / 240111113205.htm. Medical University of Vienna.

Membrane proteins frequently assemble into higher order homo- or hetero-oligomers within their natural lipid environment. This complex formation can modulate their folding, activity as well as ...