MOTH Domain: A newly identified protein fold evolved from SH3 domains, essential for recognising and binding bulky cargos during secretory pathway transport.

Suhasini R. Gopal, Yvonne T. Lee, Ruben Stepanyan, Brian M. McDermott Jr., Kumar N. Alagramam, Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model, ...

Proteins are conventionally trafficked and secreted extracellularly via the endoplasmic reticulum-Golgi pathway. Some proteins that bypass this system and use unconventional mechanisms to exit the ...

Plants contain two major types of VAMP7 proteins: VAMP71, which functions in vacuolar membrane fusion, and VAMP72, which is involved in trafficking to the plasma membrane -- part of the secretory ...

Development of luciferase-based highly sensitive reporters that detect ER-associated protein biogenesis abnormalities. iScience, 2024; 27 (11): 111189 DOI: 10.1016/j.isci.2024.111189 ...

In his 2018 work, David provided an important insight into the process of procollagen trafficking, revealing a short-loop pathway from the ER to the Golgi, without the use of large carriers. Further ...