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The findings suggest that connective tissue, and extracellular matrix proteins like lumican, operate outside of cells normally, but as disease or damage break down ECM, get sucked into and ...

New model to investigate fibrosis treatments without use of animals Date: February 1, 2022 Source: Brown University Summary: A new 3D connective tissue model gives researchers a sophisticated tool ...

“In this paper, we develop a 3D connective tissue model that enables us to directly quantify how exposing cells in a 3D environment to different nutrients, growth factors or drug treatments results in ...

The findings suggest that connective tissue, and extracellular matrix proteins like lumican, operate outside of cells normally, but as disease or damage break down ECM, get sucked into and ...

Scientists at Sanford Burnham Prebys have demonstrated that blocking macropinocytosis reshapes the tumor microenvironment, ...

During fibrosis, fibroblasts — connective tissue cells that synthesize the extracellular matrix — “become somehow dysregulated, either by injury or by mutation,” he added. “These fibroblast cells ...

The extracellular matrix (ECM) is an ideal therapeutic substrate for functional remodelling of damaged gastrointestinal (GI) tissue, owing to its composition and roles in tissue development, wound ...

More information: Hyeonji Kim et al, Extracellular matrix-based sticky sealants for scar-free corneal tissue reconstruction, Biomaterials (2022). DOI: 10.1016/j.biomaterials.2022.121941 ...

These connective tissues support and connect with other body tissues. The extracellular matrix, often known as the ECM, surrounds cells that are loosely packed in this form of tissue.