The extensive extracellular matrix (ECM) of connective tissues is a complex interacting network of proteins, glycoproteins and proteoglycans providing the dynamic and essential three-dimensional ...

The findings suggest that connective tissue, and extracellular matrix proteins like lumican, operate outside of cells normally, but as disease or damage break down ECM, get sucked into and ...

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During fibrosis, fibroblasts — connective tissue cells that synthesize the extracellular matrix — “become somehow dysregulated, either by injury or by mutation,” he added. “These fibroblast cells ...

The findings suggest that connective tissue, and extracellular matrix proteins like lumican, operate outside of cells normally, but as disease or damage break down ECM, get sucked into and ...

New model to investigate fibrosis treatments without use of animals Date: February 1, 2022 Source: Brown University Summary: A new 3D connective tissue model gives researchers a sophisticated tool ...

Cancer cells and tumors do not exist in a vacuum. Far from the isolation and self-sufficiency of the fictional Wakanda, ...

QGel’s Synthetic Matrix QGel develops 3D synthetic analogs of the extracellular microenvironments in which a variety of specific cell types, from cell lines to patient-derived tissue, grow.

Having inked a $500 million deal to work with Engitix in liver diseases in 2020, Takeda has now put up a further $300 million to expand use of the extracellular matrix (ECM) discovery platform to IBD.

Our group has explored the regeneration of soft biological tissues through cell-extracellular matrix interactions, with a focus on collagen-rich environments and fibrosis. We have developed a new ...