The recent resolution of the long-awaited structures of the central components of the complement system — C3 and factor B — has finally revealed the molecular details of complement activation ...

In a Phase 1/2a clinical study, ARO-CFB treatment in healthy volunteers achieved deep and durable reductions in the liver production of complement factor B (CFB), which is involved in alternative ...

Brief Communication Published: 02 September 2007 Variation in complement factor 3 is associated with risk of age-related macular degeneration Julian B Maller, Jesen A Fagerness, Robyn C Reynolds ...