Purespring Therapeutics has received approval for its UK clinical trial application (CTA) for a Phase I/II trial of its lead ...

Acute chest syndrome (ACS), a life-threatening complication of sickle cell disease (SCD), may be driven by overactivation of ...

To understand the complement system’s involvement in ACS, Stowell and his team assessed the blood of 27 sickle-cell-disease patients experiencing ACS for signs of complement activation.

Understanding these glycosylation patterns is just as important as analyzing other tools like labeled peptides, which are ...

Simberg and colleagues observed that this construct effectively inhibited complement activation by nanoparticles in human serum in vitro and in animal models. “ … we report that CR2-CR1 ...

For all complement-activating antibodies, C3b deposition on the surface of K. pneumoniae caused activation of complement-mediated phagocytosis and elimination by human neutrophils.

Complement activation in patients with AAV who are in remission may be reflective of ongoing renal scarring. Persistent complement activation during disease remission in antineutrophil cytoplasmic ...

Granzyme K activates the entire complement cascade. Nature, 2025; DOI: 10.1038/s41586-025-08713-9 ...

Immunoglobulin A (IgA) nephropathy is the most prevalent glomerulonephritis worldwide that does not have a specific treatment. Its pathogenesis is complex and not well understood, but there is ...

Antibodies potentially contributing to classical complement activation in six-month PASC patients were measured by phage immunoprecipitation sequencing for 87,890 epitopes in 57 patients during ...