This result suggests that vinculin may be a useful marker in distinguishing renal neoplasms with collecting duct system phenotype, such as chromophobe-type RCC, and conventional-type (clear cell) RCC.

PKD1-Dependent Renal Cystogenesis in Human Induced Pluripotent Stem Cell-Derived Ureteric Bud/Collecting Duct Organoids. Journal of the American Society of Nephrology, 2020; ASN.2020030378 DOI: 10 ...

While proximal tubule markers, CD10 and RCC-Ma, were negative (Figure 3c and d). Furthermore, the obstruction exists only in collecting duct of renal medulla and there is no adjacent cystic lesion.

CDC was first recognized as a subtype of renal carcinoma in 1986.20 Similar to chromophobe RCC, CDC, as the name implies, derives from the collecting duct cells in the medulla.

Vasopressin is known to exacerbate ADPKD cysts from collecting ducts, and when it was administered to the induced collecting ducts and renal tubules, cysts formed, albeit at a low frequency, only ...

Although cysts derived from renal tubules have been previously documented, this is the first induction of cysts from collecting ducts, which is more closely related to the pathogenesis of the disease.

On multivariable analysis, patients with papillary and collecting duct RCC had a 1.8- and 2.1-fold increased risk of death, respectively, compared with patients who had clear-cell RCC. Reference ...

“Histological subtype in patients with RCC predicts overall and cancer-specific survival. Despite adjustment for stage, patients with collecting duct and sarcomatoid RCC variants have poor ...

A protein called grainyhead-like 2 or GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation. An important process required for the kidney to produce ...

For this reabsorption to work, the renal medulla that surrounds the collecting ducts must accumulate large quantities of salt and urea.

Aldosterone secretion is influenced by the renin–angiotensin system and by the plasma potassium concentration. Renin is secreted by the juxtaglomerular cells in the afferent arteriole when renal ...