The mutated major histocompatibility complex (MHC) class I that contains donor-type epitopes displayed on recipient-type molecule was show- n to inhibit acute and chronic rejection and in-duce ...

1 Institut National de la Santé et de le Recherche Médicale, Paris, France 2 Faculté de Médecine, Université Paris Descartes, Paris, France Production of MHC-I ligands from antigenic proteins ...

Abstract The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is ...

Like MR1, CD1d is a constitutively expressed MHC class I–like molecule with some non-classical functions capable of presenting antigens to innate T cells, such as invariant NKT (iNKT) cells. iNKT ...

A common ancestor of the modern codfish acquired a set of mutations that eliminated a major arm of the adaptive immune system—the MHC II pathway of antigen presentation to CD4+ T cells ...

This suggested that the indirect pathway of allorecognition is sufficient, on its own, to cause rejection of an allogeneic skin transplant. [85, 93, 94] In another series of experiments ...