Classical MHC I molecules present antigenic peptide ... protein described to exploit an ER-associated degradation (ERAD) pathway in order to block MHC I antigen presentation (Figure 2).

whereas MHC class II ligands were believed to be solely generated from extracellular sources. Although these classical pathways of antigen presentation remain correct, it has become apparent that ...

leading to internalization into the endosome and entrance into the MHC class II pathway. Cross presentation also occurs where MHC class I molecules present extracellular antigens to CD8+ T-cells.

At a session dedicated to vaccine adjuvants and antigen presentation that was held during the recent Viral Vaccine Meeting, in Barcelona, Spain, the focus was on finding alternatives to classic ...

The newly discovered binding interaction, the LILRB1 pathway, capitalizes on a protein structure on the cancer cells' surface called the major histocompatibility complex class I, or MHC class I.

More information: Te Zhang et al, An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models, ...

They use an alternative entry pathway," says Stertz. The researchers found that hemagglutinin also binds to MHC class II protein complexes. These complexes on the surface of certain immune and ...

Viral protein is made intracellularly and the protein is processed via the endogenous MHC class I pathway. DNA vaccines. DNA vaccines favor a cell-mediated immune response. DNA plasmid vector ...