The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for ...

None of the blood samples contained SARS-CoV-2 antibodies, thus eliminating any antibody-mediated classical pathway activation of complement. C3, C5, and heparan sulfate inhibitors are not capable ...

Similar to bound C1q and anti-RBD IgG, there was a significant correlation between bound C1q and C5b-9, with rs= 0.9, indicating that the classical pathway activation following C1q binding was ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ANX1502 ...

Persistent complement activation during disease remission in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may be reflective of disease severity and organ involvement but ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ANX1502 ...