Most of the proteins and glycoproteins that constitute the complement system are synthesized by hepatocytes. But significant amounts are also produced by tissue macrophages, blood monocytes, and ...

“Annexon targets the initiating protein of the classical complement pathway, C1q, which uniquely binds to synapses in the brain and appears to cause inappropriate synapse elimination during ...

“This program harnesses our targeted anti-C1q approach, fully inhibiting the classical complement pathway with the aim of halting the damaging immune response and nerve damage that occurs in the ...

Dianthus Therapeutics, Inc. (NASDAQ: DNTH) is advancing its potential best-in-class complement inhibitor drug DNTH103 for a wide variety of autoimmune disorders. In particular, it is looking at ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ANX1502 ...

Broome CM, Röth A, Kuter DJ, et al. Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia. Blood Adv. Published online August 16, 2022 ...

Antibodies potentially contributing to classical complement activation in six-month PASC patients were measured by phage immunoprecipitation sequencing for 87,890 epitopes in 57 patients during ...

Unlike other complement blockers, Ruxoprubart does not affect the classical pathway (CP), which is critical for maintaining immunity against infections. This unique selectivity offers a significant ...

Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Thrombotic Microangiopathy Journal: Blood Published: 2024-10-03 DOI: 10.1182/blood.2024025850 Affiliations: 4 ...

The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi. Journal: Journal of Biological Chemistry Published: 2024-05-01 DOI: ...

In the alternative pathway, C3b binds to Factor B. Factor D releases Factor Ba from Factor B bound to C3b. The complex of C3b (2)Bb is a protease which cleaves C5 into C5b and C5a. C5 convertase is ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ANX1502 ...