A new study uncovers a surprising mechanism by which the SARS-CoV-2 virus, responsible for COVID-19, might cause ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ...

A new study reveals how a SARS-CoV-2 protein can mislead the immune system into damaging healthy cells, potentially ...

Researchers discover that a Covid-19 viral protein can latch onto healthy cells, prompting the immune system to mistakenly ...

The three complement activation pathways include the classical pathway, the alternative pathway, and the lectin pathway. Individuals with long COVID at six months showed increased expression of ...

The significance of this is complement inhibition similar to ... The goal for the company is to effectively target the classical C1s pathway to avoid bacterial infections with C5 inhibitors ...

The non-pegylated antigen-binding fragment (Fab) antibody ANX007 binds to and inhibits C1q, an essential component of the classical complement pathway. It demonstrated good neuroprotective ...

Complement cascades are tightly regulated ... The lectin pathway is homologous to the classical pathway, but with the opsonin, mannose-binding lectin (MBL) and ficolins, instead of C1q.

Sutimlimab is a humanized monoclonal antibody targeting the complement-specific serine protease C1s, which activates the classical component pathway. The authors said there are no therapies ...