Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

New England Journal of Medicine Source Reference: Perkovic V, et al "Alternative complement pathway inhibition with iptacopan in IgA Nephropathy" N Engl J Med 2024; DOI: 10.1056/NEJMoa2410316.

SARS-CoV-2 activates the alternative pathway through interactions with heparan sulfate. Plasma C5a levels were assessed with an ELISA in SARS-CoV-2 inoculated lepirudin-anticoagulated human blood ...

TSP-1 directly bound alternative complement pathway proteins, including factor H, factor B, C3, C5, and C8. Surface plasmon resonance analysis revealed high-affinity interactions with C5 (47 nM ...

Following 2 doses of OMS906, all patients achieved an increase in hemoglobin of ³ 4.0 g/dL, with a mean hemoglobin change from baseline of 4.75 g/dL (p < 0.001) Following 3 doses of OMS906, mean ...

Phase 1 supporting data indicated an encouraging profile and confirmed the dual mechanism of action achieved through targeting both the alternative and terminal complement pathways CAMBRIDGE, Mass ...