Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

SARS-CoV-2 activates the alternative pathway through interactions with heparan sulfate. Plasma C5a levels were assessed with an ELISA in SARS-CoV-2 inoculated lepirudin-anticoagulated human blood ...

New England Journal of Medicine Source Reference: Perkovic V, et al "Alternative complement pathway inhibition with iptacopan in IgA Nephropathy" N Engl J Med 2024; DOI: 10.1056/NEJMoa2410316.

BCX9930, an Oral Factor D Inhibitor, Suppresses Complement Alternative Pathway C3 Convertase Activity in vitro, and in Patients with Complement 3 Glomerulopathy (Poster #80); Sunday, August 28 ...

- Interim data from Phase 1/2a study demonstrate near complete inhibition in hemolytic activity and functional activity of alternative complement pathway Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) ...

TSP-1 directly bound alternative complement pathway proteins, including factor H, factor B, C3, C5, and C8. Surface plasmon resonance analysis revealed high-affinity interactions with C5 (47 nM ...

- Interim data from Phase 1/2a study demonstrate near complete inhibition in hemolytic activity and functional activity of alternative complement pathway PASADENA, Calif., December 11, 2024 ...

The company has three clinical assets, all of which target the initiating molecule of the classical complement pathway: C1q. Annexon was formed in 2011 and went public in 2020, raising net ...