Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes ...

APL-2 is an inhibitor of C3, which is involved in the classic and alternative complement pathways. Blocking C3 suppresses inflammation and affects other factors associated with disease.

Complement activation via classic and alternative pathways is emerging as a potential ... the rate-limiting step of alternative complement pathway. 60 Oral inhibitors of factor D may have a role ...

The complement system is a key component of the innate immune system, which constitutes an effective first line of defence against invading pathogens. However, inappropriate or uncontrolled ...

Multiple pathways of complement activation have been suggested in COVID-19, including both the classical and the alternative pathways of lectins, thereby making this a central mechanism of severe ...

The alternative complement pathway is essential for defense against infection by polysaccharide-encapsulated bacteria. Factor B, factor D, and properdin are required to stably initiate the process ...

BioCryst EMCHD 2022 Presentation Highlights. BCX9930, an Oral Factor D Inhibitor, Suppresses Complement Alternative Pathway C3 Convertase Activity in vitro, and in Patients with Complement 3 ...

Source Reference: Perkovic V, et al "Alternative complement pathway inhibition with iptacopan in IgA Nephropathy" N Engl J Med 2024; DOI: 10.1056/NEJMoa2410316. Secondary Source.