Journal Reference: Ivona Kubalová et al. Helical coiling of metaphase chromatids. Nucleic Acids Research, 2023 DOI: 10.1093/nar/gkad028 ...

Helical models assume that the chromatin in each sister chromatid at metaphase is arranged as a coil, whereas non-helical models suggest that chromatin is folded within the chromatids without ...

Tight control of separase activity is essential for prolonged meiotic arrest of mammalian oocytes. Here, removal of securin and cyclin B1-Cdk1 dual inhibition of separase in mouse oocytes leads to ...

“We wanted to see whether Foxp3 was benefiting from DNA loops that the regulatory T cell chromatin structure was already making, or if Foxp3 was in some way creating those characteristic loops ...

As open chromatin is often occupied by transcription factors (TFs), the researchers investigated which TFs exert potential regulatory functions after metaphase.

Study: Chromatin compartmentalization regulates the response to DNA damage. Image Credit: CI Photos / Shutterstock.com Background DNA DSBs are extremely hazardous lesions that could cause ...

These modifications increase chromatin accessibility, influencing growth, differentiation, and ion transport, with contrasting effects on normal and colorectal cancer cells. Study: Short-chain ...