At the sub-megabase genomic scale, chromatin contact and loop domains with different characteristics are readily detectable. The molecular mechanisms behind chromatin organization have not been fully ...

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic ...

An innovative strategy can enhance chemotherapy efficiency in drug-resistant cancers by stopping cells from developing ...

The eukaryotic genome is organized in the form of a highly compact nucleoprotein complex, the chromatin. Nucleosome, the basic unit of chromatin, consists of ~147 bp of DNA wrapped 1.65 times around a ...

Learning Outcomes: After attending the course, participants can expect to be able to: Perform chromatin immunoprecipitation, 3C and Capture C, and DNA methylation techniques, including experimental ...

The characterization of biological systems and of specific subdomain within them, such as chromatin, remains a difficult task. An efficient approach to gain insight in the function of protein is to ...

In the mid-1800s, Lionel Smith Beale, an English physician and microscopist at King’s College in London, peered through his microscope at a smear of saliva and mucus coughed up by a man with cancer of ...

Mitogen-activated protein kinases (MAPKs) function in all eukaryotes in signaling extracellular stimuli to intracellular responses and ultimately link them to chromatin events by targeting ...