The gene's product is an enzyme called cholesterol 7-alpha hydroxylase (CYP7A1), and it is essential for the normal elimination of cholesterol. The enzyme initiates the primary conversion of ...

Expression of the adipokine resistin-like molecule alpha (Retnla ... We show that Retnla upregulates cholesterol-7-α-hydroxylase, a key hepatic enzyme in the cholesterol catabolic pathway ...

It is well known that variation in serum lipid and lipoprotein levels is associated with the development and progression of atherosclerotic cardiovascular disease. Epidemiological studies ...

Bile acid synthesis, primarily regulated by cholesterol 7 alpha-hydroxylase (CYP7A1) and farnesoid X receptor (FXR), is another critical pathway implicated in MASLD. FXR activation reduces bile ...

Collectively, the results of this study suggest a potent antiviral activity of cholesterol 25-hydroxylase and its natural product 25-hydroxycholesterol in suppressing SARS-CoV-2 virus infection.

The gene's product is an enzyme called cholesterol 7-alpha hydroxylase (CYP7A1), and it is essential for the normal elimination of cholesterol. The enzyme initiates the primary conversion of ...