Bile acid synthesis, primarily regulated by cholesterol 7 alpha-hydroxylase (CYP7A1) and farnesoid X receptor (FXR), is another critical pathway implicated in MASLD.

Poorman JA, Buck RA, Smith SA, Overturf ML, Loose-Mitchell DS : Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits. J Lipid Res 1993; 34 : ...

The gene's product is an enzyme called cholesterol 7-alpha hydroxylase (CYP7A1), and it is essential for the normal elimination of cholesterol. The enzyme initiates the primary conversion of ...

The gene's product is an enzyme called cholesterol 7-alpha hydroxylase (CYP7A1), and it is essential for the normal elimination of cholesterol. The enzyme initiates the primary conversion of ...