100 Thus, HDAC inhibitors, or inhibitors of lysosomal acidification (e.g., chloroquine and hydroxychloroquine), may represent useful pharmacologic strategies for modulating autophagy. Current ...

The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse ...

Low pH in tumors counteracts the desired effect of the drug chloroquine, according to a new study from Karolinska Institutet in Sweden. The results, which are published in the journal Autophagy ...

More recently, chloroquine has also been used in anti-cancer treatment. Chloroquine blocks autophagy, a process that cancer cells use to survive to anti-cancer treatments. Therefore, blocking ...

Meanwhile, University of Pennsylvania oncologist Ravi Amaravadi discovered that the antimalarial drugs chloroquine and hydroxychloroquine—already known to inhibit autophagy by neutralizing ...

or by means of acute serum and amino acid withdrawal performed with the use of Earle’s balanced salt solution in the presence or absence of a late-stage autophagy blocker (chloroquine [60 μmol ...

Mix-and-Read Autophagy and Cell Viability Dyes Enable Simple, Rapid High-Throughput Screening Over the past decade, autophagy pathway has emerged as an important target in drug discovery.

They found that chloroquine inhibits autophagy during lactation and in turn allows apoptosis to proceed, pushing the breast to revert to its normal, non-lactating state. Researchers noted this ...

Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine by University of Colorado Denver The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it.

More recently, chloroquine has also been used in anti-cancer treatment. Chloroquine blocks autophagy, a process that cancer cells use to survive to anti-cancer treatments. Therefore, blocking ...