For children with lymphatic issues associated with Noonan syndrome, there were few treatments. But doctors discovered that a cancer drug might reverse it. Dec. 1, 2020, 6:49 AM PST / Source: TODAY ...

What Is Noonan Syndrome? Noonan syndrome is an autosomal dominant genetic disease, which means that if one parent has the disease, then the child will also have the disease. There are instances of ...

Noonan syndrome is a condition notable both for its frequent occurrence and phenotypic variability. It is one of the most common non-chromosomal disorders in children with congenital heart disease ...

Noonan Syndrome is associated with quite a lot of developmental problems, some of them likely to affect IQ and performance, but in spite of these difficulties a majority of children with Noonan ...

When Azneena Ariffin was told that her six-month-old daughter, Aqilah Deanna Tham Adam Tham, had a rare disease called Noonan Syndrome, she was shocked. Up until that day, she had never even heard ...

To identify candidate genes, a group led by HMS instructor Amy Roberts, MD, and director of HPCGG Raju Kucherlapati, PhD, conducted genetic analysis of over 100 children with Noonan syndrome.

A study of 25 children with Noonan syndrome ranging in age from 2 months to 12 years revealed that 16 had gastrointestinal symptoms such as reflux and failure to thrive. [5] ...

Researchers at Children's Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, fluid collection ...

SOS1 -mediated Noonan syndrome can have a mild phenotype, which may not be apparent until the child becomes older, when neurocognitive findings become more noticeable, as seems to be the case with ...

Noonan syndrome is now known to be a genetically heterogeneous disorder with practically one half of all cases caused by gain-of-function mutations in PTPN11, the gene encoding the SHP-2.

To identify candidate genes, a group led by HMS instructor Amy Roberts, MD, and director of HPCGG Raju Kucherlapati, PhD, conducted genetic analysis of over 100 children with Noonan syndrome.