The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

This paradigm shift from conventional treatments offers a more precise method to neutralize cancer cells. The cGAS-STING signaling pathway, a key element of the innate immune response, has risen ...

Development of a new nano-immune agonist to improve immunotherapy for melanoma, a challenging skin cancer, by changing the ...

Sure enough, we found that ruptured micronuclei were potent activators of cGAS and its partner protein STING, leading to innate immune activation. But unlike acute viral infection, which only lasts ...

Researchers have developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for ...

I was initially drawn to cancer research and became fascinated ... recognizes self DNA released by stressed or damaged cells. The cGAS-STING pathway begins with an enzyme called cGAS-sensing ...

Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded the 2024 Albert Lasker Basic Medical Research Award for the discovery of the cGAS ... of STING.

As a result, cytoplasmic DNA accumulates, activating the STING–cGAS pathway (a key viral ... Importantly, STACT-TREX1 induces tumor-specific killer T cells. TREX1 knock-down overwrites the ...

In addition, research is focused on protein-RNA complexes mediating the piRNA pathway (with Julius Brennecke, IMBA-Austria), on identification and characterization of small molecule inhibitors ...