In fact, over 90 percent of drug candidates that show promise in preclinical studies ultimately fail in clinical trials, largely due to the limitations of traditional models. 3D cell culture provides ...

A novel 3D human cellular model Cognitive decline associated with Alzheimer’s disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive ...

Burst of rapid cell motion in 3D tumor model Researchers discover phenomenon to help explain cancer metastasis Date: March 16, 2022 Source: University of Göttingen Summary: Biological processes ...

Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model. Nature Neuroscience, 2023; DOI: 10.1038/s41593-023-01415-3 ...

The Advanced Cell Engineering and 3D Models (ACE-3M) Core provides established services offered previously by AIM and C-BASS cores plus new expanded capabilities for tumor organoids grown in 3D ...

In this study, a screening was carried out utilizing patient-derived 3D spheroids (tumoroids). In addition to readouts on cell viability, the Cell Painting assay was adapted for the 3D tumor model.

Credit: N. Antón-Bolaños et al./Nature For the first time, researchers have grown 3D models of the brain that include a wide variety of cell types from several people 1.

In APL Bioengineering, from AIP Publishing, researchers from the University of Minnesota-Twin Cities and Mayo Clinic in Rochester, Minnesota, describe a 3D cell culturing platform that allows ...

Scientists have successfully immortalized lip cells, allowing new treatments for injuries and infections to be trialed on a clinically relevant lab-based model We use our lips to talk, eat, drink ...

More information: Yanli Wang et al, Reconstructing 3D chromosome structures from single-cell Hi-C data with SO (3)-equivariant graph neural networks, NAR Genomics and Bioinformatics (2025).