The quest to resurrect the woolly mammoth on Earth has taken another, well, small step with the creation of the Colossal ...

Caption CRISPR RNP (CRISPR SNA at work: in complex with single-guide RNA (red), CRISPR SNA can recognize and cleave the gene target of interest (yellow)). The complexed form of Cas9 protein and ...

Generally, Cas9/sgRNA is delivered via viral transduction, ribonucleoprotein (RNP) electroporation, or plasmid transfection method. 2 Compared to all delivery methods, RNP electroporation ...

For example, advances have been made in base editors, which use a mutated Cas9 nuclease to target DNA ... editors in LNP-based ribonucleoprotein (RNP) complexes. The method was effective in ...