The L-type Ca 2+ channel (LTCC ... such as cardiac hypertrophy and heart failure 8. Targeting of LTCCs to t-tubules is believed to control contractility via calcium-induced calcium release ...

Calcium-Induced Calcium Release (CICR) Within Cardiac Myocytes Excitation-contraction ... the SR-calcium ion release channel. These are called ryanodine receptor 2, or RyR2. The open probability ...

RYR-2 opens when the myocyte is signaled ... concerning the mechanism of cardiac dysfunction could inform the development of a new type of drug (ie, a calcium channel stabilizer) for treatment ...

Calcium plays a variety of roles in signaling ... the heart muscle and the contractile mechanism, which causes the cardiac myocytes to contract and enables the heart to pump blood.

Iowa City, IA - A pair of laboratory studies published this month point to possible roles for calcium and calmodulin ... part because its expression in cardiac myocytes had not been previously ...

The researchers are quick to emphasize that verapamil is NOT an appropriate treatment for DM1 in humans due to its potential cardiac side effects. "We think that the calcium channel is a new ...