By organizing the rest of the heart cell, cBIN1 helps restore critical functions of heart cells. "cBIN1 is bringing benefits to multiple signaling pathways," Li adds.

Indeed, the gene therapy seemed to improve heart function on the microscopic level, with better-organized heart cells and proteins. The researchers hope that cBIN1's role as a master regulator of ...

Cell Structure and Function: The PITX2-deficient heart cells are shorter and more disorganized, with more cells having single nuclei. These cells also have smaller mitochondria and changes in the ...

Heart attacks remain a leading cause of death and disability worldwide. The permanent loss of heart muscle cells-known as ...

A naturally occurring fat molecule reduced heart inflammation and scarring caused by diabetes, thereby improving cardiac function, according to new research. The findings open the door to ...

A preclinical study led by the Smidt Heart Institute at Cedars-Sinai challenges the assumption that blocking the NCX1 protein ...

Previous attempted therapies for heart failure have shown improvements in heart function on the order of 5–10%. cBIN1 gene therapy improved function by 30%. “It’s night and day,” Shaw added.

November 22, 2011 (Orlando, Florida) — Results from a small phase 1 study provide some reason for optimism in the treatment of ischemic cardiomyopathy with autologous cardiac stem cells (CSCs) [1].