Calcium-Induced Calcium Release (CICR) Within Cardiac Myocytes Excitation-contraction coupling occurs within cardiac muscle cells in response to calcium-induced calcium release, CICR.

Atrial myocytes were enzymatically dissociated from biopsies of human right atrial appendages of infant (3–8 mo) patients who were undergoing open-heart surgery. Intracellular calcium transients ...

Blocking β-adrenergic receptors is a standard treatment for heart failure, but it limits the normal ability to modulate cardiac function. Targeting therapy further downstream by blocking ...

Introduction of selected, pure human cardiomyocytes derived from induced pluripotent stem cell (hiPSCM) into a calcium transient imaging high throughput screening (HTS) assay to assess cardiotoxicity ...

Researchers have developed a novel method for simultaneously recording action potentials (APs)—temporary changes in electrical potential when cells become excited—and calcium transients ...