Invalidation of Wolframin Leads to Elevated Contraction and Prolonged Calcium Transients. Contractile and calcium transient responses of isolated cardiac myocytes to field or caffeine stimulation (six ...

Calcium homeostasis in cardiac myocytes results from the integrated function of transsarcolemmal Ca2+ influx and efflux pathways modulated by membrane ... One-dimensional scanning multiphoton imaging ...

Cardiac excitation–contraction coupling (ECC) is the orchestrated process of initial myocyte electrical excitation, which leads to calcium entry, intracellular trafficking, and subsequent sarcomere ...

A microfluidic method to study the contraction of a single cardiac myocyte (heart muscle cell) has been developed. This method integrates various single-cell operations as well as on-chip dye loading, ...

Calcium Signaling plays a central role in the contraction of the heart. It couples the electrical excitation of the heart to contraction. The importance of calcium signaling extends well beyond this ...

Blocking β-adrenergic receptors is a standard treatment for heart failure, but it limits the normal ability to modulate cardiac function. Targeting therapy further downstream by blocking ...

Depressed contractility is a central feature of the failing human heart and has been attributed to altered [Ca2+]i. This study examined the respective roles of the L-type Ca2+ current (ICa), SR Ca2+ ...

Atrial myocytes were enzymatically dissociated from biopsies of human right atrial appendages of infant (3–8 mo) patients who were undergoing open-heart surgery. Intracellular calcium transients ...

Introduction of selected, pure human cardiomyocytes derived from induced pluripotent stem cell (hiPSCM) into a calcium transient imaging high throughput screening (HTS) assay to assess cardiotoxicity ...