a, Calcium/calmodulin (Ca 2+ /CaM)-dependent transcriptional pathways that reprogram cardiac gene expression. Activated calcineurin enables translocation of NFAT to the nucleus, where it ...

US-based Cardurion Pharmaceuticals has completed enrolment in two multi-centre, global Phase II CYCLE trials of the orally-administered phosphodiesterase 9 (PDE9) inhibitor, CRD-750, targeting both ...

News Release 8-Feb-2005 New math model of heart cell has novel calcium pathway Advance helps in arrythmia research Peer-Reviewed Publication Washington University in St. Louis ...

Spiperone Enhances Intracellular Calcium Level and Inhibits the Wnt Signaling Pathway Desheng Lu; Dennis A Carson Disclosures BMC Pharmacol. 2009;9 (13):1-8.

Transcription factors such as NF-AT, kinases, and phosphatases, and calcium-binding protein calmodulin (CaM) are all impacted by calcium activity. Calcium signaling and disease ...

Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) has emerged as a pivotal molecule in transducing calcium signals via its interaction with calmodulin. This kinase modulates several ...

A new study led by University of Iowa researchers has found an unexpected new link between inflammation in heart muscle following a heart attack and a previously known enzyme called calcium ...

Interrupting the interaction between p68 and calcium-calmodulin, which is essential for cell migration, inhibited metastasis. The findings were recently published in Nature Communications.

Experiments show that calcium, when bound to a protein called calmodulin, prompts plants to make salicylic acid (SA) when threatened by infection or other danger. SA is a close chemical relative ...

Calcium has been implicated as an important mediator of antagonism of canonical Wnt signaling, acting at multiple points in the canonical Wnt pathway. [5, 7, 8] ...