Background: Trabectedin (T) is extensively metabolized via the cytochrome P450 (CYP) 3A4 enzyme. Drug-drug interaction studies of T coadministered with rifampin (CYP3A4 inducer) and ketoconazole ...

CAMZYOS is an inducer of CYP3A4, CYP2C9, and CYP2C19. Concomitant use with CYP3A4, CYP2C19, or CYP2C9 substrates may reduce plasma concentration of these drugs.

Cigarette smoke contains compounds that significantly affect drug interactions in clinical settings, primarily through the induction of cytochrome P450 (CYP) enzymes. Given the complexity of cigarette ...

Clopidogrel appears to be activated by the same enzyme that metabolizes several of the lipophilic statins, suggesting that a hydrophilic statin may be preferable when the 2 agents are given ...

The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified ...

Discussion In this illustrative case, adrenal insufficiency developed in our patient when ritonavir, a potent inhibitor of the cytochrome P450 (CYP) 3A4 pathway, was withdrawn. Ritonavir inhibited the ...

Anamorelin is metabolized in the liver, primarily by the CYP3A4 isoenzyme. Strong inducers/inhibitors of CYP3A4 might change its PK profile. Methods: Two phase I clinical trials in healthy volunteers ...

Large individual variability exists in response to clopidogrel, which appears to be due to differing levels of the CYP3A4 enzyme, new data suggest. Another study shows clopidogrel may be of ...