CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein ...

Auxin-inducible degron 2 system deciphers functions of CTCF domains in transcriptional regulation. Genome Biology, 2023; 24 (1) DOI: 10.1186/s13059-022-02843-3 ...

As compared to all CTCF binding sites, those for P-CTCF had significantly higher mutational rates in prostate and breast cancers. In all 12 examined cancer types, projected P-CTCF binding sites ...

CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion. Nature, 2023; DOI: 10.1038/s41586-023-05961-5 ...

Only one side of the CTCF protein is able to interact with cohesin. Then again, it doesn’t always do this, because we thought CTCF would also fail frequently. But now we have measured it.

Alexey A. Gavrilov, Rinat I. Sultanov, Mikhail D. Magnitov, Aleksandra A. Galitsyna, Erdem B. Dashinimaev, Erez Lieberman Aiden, Sergey V. Razin, RedChIP identifies noncoding RNAs associated with ...

Sophie Beer, Lucas E. Wange, Xiang Zhang, Cornelia Kuklik-Roos, Wolfgang Enard, Wolfgang Hammerschmidt, Antonio Scialdone, Bettina Kempkes, EBNA2-EBF1 complexes promote MYC expression and metabolic ...