In their preclinical model, the researchers found efficacy both in vitro and in vivo by using CRISPR-Cas9 to mimic porphyria and combining the technology with light therapy. Their approach ...

Using CRISPR-Cas9, scientists can make precise changes to the genome during brain development, and then closely study how those changes affect individual cells using single-cell transcriptomic ...

Introduction: Why CRISPR Screening Still Feels Slow CRISPR-Cas9 technology has revolutionized gene editing, but biotech teams ...

In the study, "Targeting the SHOC2–RAS interaction in RAS-mutant cancers," published in Nature, researchers conducted a genome-wide CRISPR screen to identify genetic dependencies associated with ...

The application broadly encompassed CRISPR-Cas9 genome-editing technology invented by the Doudna-Charpentier team and its applications in any setting, UC said, including in vitro, and cellular and ...

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study. Down syndrome is caused by the presence of a third copy ...

CRISPR Therapeutics AG stock has soared 90% since May, driven by Casgevy approval and future breakthroughs in gene editing.

A team from UC San Diego, John Hopkins and UC Berkeley Universities found a way to edit a single gene in a mosquito that ...

More information: Ryotaro Hashizume et al, Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf022 ...