It is unclear if COX-2-selective NSAIDs also inhibit COX-3 and whether this inhibition could represent a primary central mechanism by which these drugs decrease pain and possibly fever.

Over-the-counter NSAIDs inhibit both COX-1 and COX-2, but some, like aspirin and Aleve, are more selective for COX-1. Advil is considered non-selective. Examples of prescription NSAIDs that are ...

Celebrex (celecoxib) is a selective NSAID. It differs from non-selective NSAIDs because it targets the COX-2 enzyme, ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

The synthesis of prostaglandins is blocked by the aspirin-like drugs (NSAIDs ... the COX2 selective inhibitors — with improved tolerance. There may be other forms of COX that could account ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...