Achieved rapid (within two hours) and maximal (median >99 percent relative to pre-dose levels) suppression of the generation of C3a, a product of C3 convertase activity, in both healthy volunteers ...

When SCIN is bound to C3 convertase, the enzyme can no longer generate C3b and amplify the complement response, which likely renders the immune system less effective against staphylococcal infections.

These patients, exemplified by the family with DDD reported by Martínez-Barricarte et al., 22 may have a mutant C3 convertase that is resistant to factor H control and would thus require specific ...

As C3b itself is a critical part of the AP C3 convertase, its generation feeds upon itself; newly generated C3b has direct effector functions and forms additional C3 convertase molecules.

The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for ...

It also binds C3 convertase to form C5 convertase, which produces C5a, a small peptide mediator of inflammation, and C5b, a component that begins the ‘late’ stages of complement activation.

Moreover, Simberg and colleagues also showed that complement system activation is a dynamic and ongoing process - blood proteins and C3 convertase constantly dissociate from nanoparticles, and new ...

Apellis Pharmaceuticals Inc. has identified C3 convertase inhibitors reported to be useful for the treatment of cancer, obesity, infections, neurological disorders, autoimmune and inflammatory ...

Both patients lacked C3 nephritic factor but had autoantibodies to the two individual components of the C3 convertase (i.e., C3b and factor B) (Figure 1A).